Pinnaratip, rattapol, effect of silica micro nano particles incorporation over bioinspired poly ethylene glycolbased adhesive hydrogel, campus access masters report, michigan technological university, 2017. Us6565873b1 us09696,120 us69612000a us6565873b1 us 6565873 b1 us6565873 b1 us 6565873b1 us 69612000 a us69612000 a us 69612000a us 6565873 b1 us6565873 b1 us 6565873b1 authority us united states prior art keywords particles nano system active agent core prior art date 20001025 legal status the legal status is an assumption and is not a legal conclusion. Chapter introduction to bioadhesive drug delivery pathophysiology of diseases that are currently among the leading causes of death now require much more than just a stethoscope for diagnosis and a pill for treatment. T kalaichelvan 1 1centre for advanced studies in botany, university of madras, chennai 600 025, india 2 kongu arts and science college, erode 638 001. The bnps also showed much higher attachment to usc cells fig. After incubation and extensive washing, the bnps showed much higher retention on the poly l lysine coated plates fig. Nanoparticles are solid colloidal particles ranging in size from about 10 to nm 1. Most mucosal surfaces such as in the gut or nose are covered by a layer of mucus. Interfacial cohesion and assembly of bioadhesive molecules for design of longterm stable hydrophobic nanodrugs towards effective anticancer therapy guizhi shen 1,2, ruirui xing, ning zhang 1, chengjun chen1, guanghui ma, xuehai yan1,2 1state key laboratory of biochemical engineering, institute of process engineering. Nov 30, 2018 home bioadhesive nanoparticles for protection and treatment of human skin. The ratio of uv filters within nanoparticles nps was optimized for filterfilter. The bioadhesive rapamycinloaded plga nanoparticles were obtained by applying carbopol 940 of different concentrations as stabilizer and bioadhesive agent.
Depending on the method of preparation, nanospheres or nanocapsules. Pdf forensic fingerprint enhancement using bioadhesive. Encapsulation of the uvb filter padimate o within bioadhesive biodegradable nanoparticles bnps composed of polyd, l. Zwp nanoparticles enhanced the oral bioavailability of lpv and fenretinide by 4 and 7fold, respectively. Plotting the amount of adhered particles in the whole gut versus time enabled us to determine the affinity of the formulation for the biological support expressed as q max, the intensity and relative duration of the bioadhesive phenomenon auc adh and mrt adh, respectively, and the elimination rate of the adhered particles k adh. Bioadhesive coating improves intestinal absorption into the. Invitro drug release study for glutaraldehyde cross linked gelatin nanoparticles were found between 67. Biosynthesis of silver nanoparticles from orange peel. Discher, synthetic cells selfassembling polymer membranes and bioadhesive colloids, annu. Synthesis of bioadhesive polyacrylic acid nano and. They can be administered via 1 vaginal route in the form of suppositories, vaginal gel, and pessaries. Us20030147956a1 us10376,761 us37676103a us2003147956a1 us 20030147956 a1 us20030147956 a1 us 20030147956a1 us 37676103 a us37676103 a us 37676103a us 2003147956 a1 us2003147956 a1 us 2003147956a1 authority us united states prior art keywords system nano particles zinc active agent prior art date 20001025 legal status the legal status is an assumption. Design strategies and applications of tissue bioadhesives. Bioadhesive matrix tablets loaded with lipophilic nanoparticles as.
Bioadhesive nanoparticles for protection and treatment of human skin speaker. Bioadhesive food protein nanoparticles as pediatric oral. Results and discussion antioxidative properties of nds, c 60, and vitamin c. Bioadhesive and mucoadhesive polymers authorstream presentation. Forensic fingerprint enhancement using bioadhesive chitosan and gold nanoparticles. May 20, 2003 the altering of either, or both, the inner solid core or the outer surfactant layer can manipulate the release rate of the substance from the nano particles. Polyvinyl methyl ethermaleic anhydridedoped pegpla. Sep 28, 2015 a waterresistant sunblock based on bioadhesive nanoparticles encapsulating a model ultraviolet filter at low concentrations adheres to the stratum corneum without subsequent intraepidermal or. Most commercial sunblocks are good at preventing sunburn, but they can go below the sk. In both ex vivo and in vivo studies, zwp nanoparticles were found to be strongly bioadhesive.
Degradable bioadhesive nanoparticles for prolonged. The api will be released close to the site of action with a consequent enhancement of bioavailability mucoadhesive drug delivery systems provide a means of enhancing retention at defined sites, if systemic uptake occurs the use of mucoadhesive polymers will not prevent a. Applications of nanoparticles in biology and medicine. Farming of natural organisms small and large that secrete bioadhesive materials. Here, we show that a unique formulation of bioadhesive nanoparticles bnps can interact with mesothelial cells in the abdominal cavity and. The bioadhesive nanoparticles mnps demonstrated both mucus permeation and epithelial absorption, and thus, this bioadhesive drug delivery system has the potential to improve the bioavailability of drugs that are insoluble in the gastrointestinal environment. Biosynthesis of silver nanoparticles from orange peel extract and its antibacterial activity against fruit and vegetable pathogens p. Biodegradable bioadhesive controlled release system of. Now, due to bioadhesion, the immobilization of drug carrying particles at the mucosal. While transdermal penetration of the inorganic particles appears to be less of a concern than for the organic agents 21, both types of sunblock agents have shown the capacity to enhance ros generation after uv exposure, suggesting that even small quantities may contribute to cellular damage and ultimately carcinogenesis 2225. It has attracted much attention in catalysis, optoelectronics and biology due to its unique physical and chemical properties.
The adhesive potential of gantrez was found to be stronger when folded as nanoparticles than in. Although the sunblock based on bnps contained less than 5 wt% of the uvfilter concentration found in commercial standards, the antiuv effect was comparable when tested in two murine. To facilitate quantification of their bioadhesive properties. Metal oxide ceramic nanoparticles can also be used to create thin layers, whether crystalline or amorphous. The goal of this study was to develop bioadhesive food protein nanoparticles using zein z, a hydrophobic corn protein, as the core and whey protein wp as the shell for oral pediatric drug delivery applications. Zwp nanoparticles enhanced the permeability of lpv and fenretinide across caco2 cell monolayers. Bioadhesive food protein nanoparticles as pediatric oral drug. Preparation, characterization and stabilization of nano.
Kumara a koringa college of pharmacy, korangi 533 461, tallarevu m, e. Bioadhesives are natural polymeric materials that act as adhesives. Bioadhesive nanoparticles help protect your skin from the sun. Comparative uptake studies of bioadhesive and nonbioadhesive. Further inhaled substances deposit on the mucus layer, which coats the walls of the conducting airways. They can be in the form of powder, sponges, sheets or micro particles. In principle any collection of atoms bonded together with a structural radius of bioadhesive protein genes.
Pdf use of nanotechnology in food processing, packaging. Lopinavir lpv, an antiretroviral drug, and fenretinide, an investigational anticancer agent, were used as model drugs in the study. Molecules and particles as nano and microscale drug carriers last time. Preparation and characterization bioadhesive chitosan nanoparticles cs nps were prepared for. Most importantly, mp was significantly less cytotoxic when compared to np when these particles were directly exposed to l929 fibroblast. Degradable bioadhesive nanoparticles for prolonged intravaginal delivery and retention of elvitegravir. So they are considered good candidates for drug or gene delivery systems. To enhance topical retention of sunscreen formulation, nnps were converted into bioadhesive nps bnps by selectively oxidizing. Chapter 1 introduction bioadhesive drug to delivery.
In addition, bioadhesive dosage forms have been used to target local disorders at the mucosal surface e. The formation of biofilm by streptococcus mutans on the tooth surface is the primary cause of dental caries and periodontal diseases, and fluoride f has shown tremendous potential as a therapeutic moiety against these problems. Antibiotics were loaded into polymeric nanoparticles and then embedded into a 3d hydrogel network that confers adhesion to biological surfaces. Development and characterization of bioadhesive film embedded. Bnps are readily suspended in water, facilitate adherence to the stratum corneum without subsequent intraepidermal or follicular penetration. A bioadhesive nanoparticlehydrogel hybrid system for. In pharmacy its all about synthesizing, characterizing and screening the particle at nano range.
Bioadhesive coating improves intestinal absorption into. New approach for local delivery of rapamycin by bioadhesive plgacarbopol nanoparticles weiwei zou1, guangqing cao2, yanwei xi1. A more specific term than bioadhesion is mucoadhesion. The method for the preparation of these nanoparticles would lend itself to the encapsulation of hydrophilic drug candidates, since the external phase of the emulsion systems consists of paraffin.
A sunblock based on bioadhesive nanoparticles nature materials. The bioadhesive nano particle compositions of the present invention can generally be incorporated into any suitable oral hygiene product known in the art. Orabase was the first marketed bioadhesive formulation prepared by using natural gums as bioadhesive materials. We first evaluated the bioadhesive property of the three nanoparticles on poly l lysinecoated surfaces.
Us6565873b1 biodegradable bioadhesive controlled release. Synthesis and characterization of novel modified and. The bioadhesive properties of the polymerized paa particles are very promising because they exhibit adhesive forces comparable to those of polycarbophil. Dermatologists from yale university have developed a new sunscreen made with bioadhesive nanoparticles that doesnt penetrate the skin, eliminating serious health concerns associated with commercial sunscreens. In vitro drug release was analyzed by incubating the nps in 0.
Contents of liposomes introduction mechanism of liposome formation. Currently, a large number of bioadhesive products are commercially available due to ease of manufacturing, minimal toxicity, and ease of administration kumar et al. Interfacial cohesion and assembly of bioadhesive molecules. This work summarises some experiments describing the bioadhesive potential of gantrez nanoparticles fluorescently labeled with rhodamine b isothiocyanate. In this work, bioadhesive buccal tablets, consisting of a hydrophilic matrix loaded with metronidazole and lipophilic nanoparticles as a vehicle of curcumin, were developed. Pdf bioadhesive properties of gantrez nanoparticles.
Us20030147956a1 biodegradable bioadhesive controlled. Curcumin curloaded nanostructured lipid carriers nlc were prepared using glycyrrhetic acid, hexadecanol, isopropyl palmitate and tween80 as a surfactant. Biodegradable bioadhesive nanoparticle incorporation of. Now, due to bioadhesion, the immobilization of drug carrying particles at. A sunblock based on bioadhesive nanoparticles nature. It appears your web browser is not configured to display pdf files. Here, we show that the encapsulation of padimate o poa model uv filterin bioadhesive nanoparticles bnps prevents epidermal cellular exposure to uv filters while enhancing uv protection. Microspheres are small spherical particles, with diameters in the micrometer range typically 1. At each time point, the particles were filtered at 3,500 g for 10 min, the nps were resuspended in 0. Effect of incorporating clustered silica nanoparticles on the.
Promising results in the potential use of bioadhesive particles for orally administered drugs orally administered medications have always faced challenges such as overcoming the acidic environment of the stomach, ensuring sufficient uptake in the intestines and targeting to the cor. Mark saltzman 1 1 department of biomedical engineering, yale university, 55 prospect street, new haven, ct 06511, usa. The drug is released slowly at the desired rate, and the system is found to. Biodegradable bioadhesive controlled release system of nano. Here, we report the development, and in vitro and in vivo assessment of a bioadhesive vaginal film as a coitallyindependent mpt dosage form for delivering dapivirine dpv and levonorgestrel lng to prevent hiv infection and unintended pregnancy, respectively. The composite adhesives were sterilized using ethanol following a published protocol 34. Preparation, characterization and stabilization of nano sized copper particles. Herein, we report an efficient multiingredient bioadhesive filmbased delivery system for oral cavity to combat dental problems with an ease of administration. Bioadhesive coating improves intestinal absorption into the bloodstream of drugcarrying nanoparticles nanowerk news for proteinbased drugs such as insulin to be taken orally rather than injected, bioengineers need to find a way to shuttle them safely through the stomach to the small intestine where they can be absorbed and distributed by the bloodstream. Molecules and particles as nano and microscale drug carriers. Nanoparticles nanoparticles are the simplest form of structures with sizes in the nm range. A variety of applications where the selfassembly of nanoparticles might be useful.
Inspired by delivery systems mimicking marine mussels for adhesion, herein, we developed a bioadhesive nanoparticlehydrogel hybrid npgel to enhance localized antimicrobial drug delivery. Bioadhesive nanoparticles for protection and treatment of. Us6790460b2 biodegradable bioadhesive controlled release. The present invention relates to a controlled release system useful for site specific delivery of biologically active ingredients or sensory markers, over an extended period of time, targeting biological surfaces comprising the oral cavity and mucous membranes of various tissues, as well as the controlled release of the biological active ingredients or sensory markers. The altering of either, or both, the inner solid core or the outer surfactant layer can manipulate the release rate of the substance from the nano particles. Effect of incorporating clustered silica nanoparticles on. Biodegradable bioadhesive nanoparticle incorporation of broad. Bioadhesive hpmc gel containing gelatin nanoparticles for. Their unique sizedependent properties make these materials superior and indispensable in many areas of human activity. Incorporation of these nps into the polymer matrix is one of the best methods to display their special functions, which not only stabilize the nps but also realize the functional assembly of nps and. The term is sometimes used more loosely to describe a glue formed synthetically from biological monomers such as sugars, or to mean a synthetic material designed to adhere to biological tissue bioadhesives may consist of a variety of substances, but proteins and carbohydrates feature prominently. Uv protection and antioxidant activity of nanodiamonds and. Development and characterization of bioadhesive film. The nd exhibits antioxidant properties by promoting the reduction of.
Polymers free fulltext bioadhesive matrix tablets loaded. Nanomaterials are at the leading edge of the rapidly developing field of nanotechnology. In situ preparation of nanoparticlespolymer composites. Rational design of a multipurpose bioadhesive vaginal film. Dermatologists from yale university have developed a new sunscreen made with bioadhesive nanoparticles that doesnt penetrate the skin, eliminating serious health concerns associated with commercial sunscreens most commercial sunblocks are good at preventing sunburn, but they can go below the skins surface and enter the bloodstream. Bioadhesive hpmc gel containing gelatin nanoparticles for intravaginal delivery of tenofovir sreejan mannaa, uppadi swathi lakshmi a, manasa racharlaa, pratyusha sinhab, lakshmi kanta kanthal, s. A sunblock based on bioadhesive nanoparticles yang deng, 1, asiri ediriwickrema, 1, fan yang, 1 julia lewis, 2 michael girardi, 2 and w. The optical properties of small metal nano particles are dominated by the collective oscillation of conduction electrons resulting from the.
Insulin was chosen as a model drug, being loaded on these surfacemodified silica nano particles, and in vitro release profiles was established at ph 7. Pdf bioadhesive nanoparticles have been proposed as carriers for the oral delivery of poorly available drugs and facilitate the use of this. Nanoparticles as potential oral delivery systems of proteins and. Preparation of pegfp loaded bioadhesive plga nano particles. The study of selfassembly of nanoparticles began with recognition that some properties of atoms and molecules enable them to arrange themselves into patterns. Bioadhesive nanoparticles for protection and treatment of human skin. Nanotechnology is the act of purposefully manipulating matter at the atomic scale, otherwise known as the nanoscale. There was no statistical difference between the measured values for np and mpincorporated adhesives, indicating that mp was equally as effective in enhancing the material properties of pegda as np. Comparative uptake studies of bioadhesive and nonbioadhesive nanoparticles in human intestinal cell lines and rats.
The oxidation of the nonadhesive nanoparticles has resulted in the formation of bioadhesive nanoparticles, owing to the conversion of vicinal. Bioadhesive plga nanoparticles nps were prepared following the methods described previously by our group 16. Ceramic nanoparticles, like metallic nanoparticles, can also be formed into coatings and bulk materials at lower temperatures than their non nano counterparts, reducing manufacturing costs. Bioadhesive nanoparticles have been proposed as carriers for the oral delivery of poorly available drugs and facilitate the use of this route. New approach for local delivery of rapamycin by bioadhesive. To quantitate bioadhesion, we tested nanoparticles at various states of aldehyde activation by examining attachment to polyllysinecoated plates and usc cells fig. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Chitosan particles can act as bioadhesive cationic polyelectrolytes. Quantification of the bioadhesive properties of protein.
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